However, most men can expect to live a long, full life. Klinefelter syndrome is caused by an additional X chromosome in males (47,XXY). Klinefelter syndrome is quite common, affec… Men with serum testosterone less than 300 ng/dl received medical therapy with aromatase inhibitors, clomiphene or human chorionic gonadotropin before microdissection testicular sperm extraction. Testosterone replacement therapy: Since males with Klinefelter syndrome don't produce enough testosterone, undergoing testosterone replacement therapy at the onset of puberty can allow a … Treatment is usually in the form of an injection, pills, gel, or a patch. Klinefelter syndrome is a fairly common genetic condition found in males only.. In 1942, Klinefelter et al published a report describing nine men with a constellation of features: testicular dysgenesis, microorchidism, eunuchoidism, gynecomastia, elevated urinary gonadotropins, and azoospermia. Treatment involves the targeted administration of male hormones (androgens), such as testosterone enanthate, cypionate, or androgel. Males with Klinefelter syndrome should be seen by a team of health care providers. Materials and methods: A total of 91 microdissection testicular sperm extraction attempts were done in 68 men with nonmosaic Klinefelter's syndrome. Klinefelter syndrome is a genetic condition that affects males physical, behavioral, and cognitive development and functioning. Often it is only at puberty that these symptoms are noticed. With treatment, men can lead very normal lives. Some treatments for the symptoms of Klinefelter syndrome can include: Hormone replacement. Klinefelter syndrome can shorten a male’s life expectancy up to two years. This results in stunted puberty, smaller than average genitals, and the development of breasts and infertility. Often, symptoms are subtle and subjects do not realize they are affected. KS is also called 47, XXY. Klinefelter syndrome is an uncommon genetic disorder, and it can only be diagnosed after laboratory tests are completed to determine if an individual has the disorder. The syndrome can affect boys and men at different stages of life and their physical, language, and social development. Testosterone replacement therapy improves, strength, body hair growth, … It was clinically described for the first time by Kleinfelter in 1942. Off Label. About Klinefelter Syndrome Klinefelter Syndrome (KS) is a condition that occurs in men who have one or more extra X chromosomes. Treatment of Klinefelter syndrome may include: Genetic counseling to discuss long-term complications Special education programs (including speech therapy, occupational therapy, or other therapies) Surgery. In some cases, surgery may be necessary to correct certain symptoms of Klinefelter syndrome, such as abnormal breast tissue. Females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). Klinefelter syndrome is a genetic disorder caused by the acquirement of an extra X chromosome in males (XXY instead of XY). Since there are low levels of testoterone in Klinefelter syndrome, the number one treatment suggested is testosterone replacement therapy to prevent the severe lifelong effects of the disorder. Other treatments for Klinefelter syndrome include: speech and language therapy physical therapy to improve muscle strength occupational therapy to help you function day to … The following are the proposed remedies of the syndrome: Androgen therapy. What is the treatment for Klinefelter syndrome? Our doctors work with patients’ primary care providers to identify specialty needs, to coordinate care, and to improve outc… A person with KS has 47 chromosomes inside their cells instead of the usual 46. Mild cases of Klinefelter syndrome may require no treatment. Treatment of Klinefelter Syndrome Klinefelter Syndrome is a genetic mutation, and hence it has no cure but certain pharmacological therapies can … In a few of these individuals, sperm obtained from the testes have successfully fertilized oocytes in vitro. Early intervention can prevent some symptoms from occurring. Appointments & Access. What Is Klinefelter Syndrome? The population frequency is 1: 1000 males. Klinefelter syndrome can be diagnosed through genetic testing, semen analysis and blood tests to measure hormones. 47, XXY is the most common of the X and Y variants and approximately, 1 in 500 males has an extra copy of the X chromosome. The treatment for Klinefelter syndrome is aimed in addressing the major manifestations of the disease. Clinical Features of Klinefelter Syndrome Groth K et al. Klinefelter syndrome (KS) is a genetic condition in which boys are born with an extra copy of the X chromosome (piece of genetic material). Men with Klinefelter syndrome can now have children, if they want, with new forms of in-vitro fertilisation. The MassGeneral Hospital for Children Klinefelter Syndrome clinic takes a multidisciplinary approach to providing quality, coordinated care to individuals living with Klinefelter syndrome. The team may include endocrinologists, general practitioners, pediatricians, urologists, speech therapists, genetic counselors, and psychologists. This treatment should begin at puberty or as soon after as possible. Klinefelter syndrome treatment. Klinefelter syndrome treatment with homeopathy is also prominent for treating secondary symptoms. While Klinefelter syndrome cannot be cured, some of its symptoms can be improved by testosterone replacement therapy, which restores testosterone levels to normal range. Treatment typically involves physical and emotional therapy, as well as hormone replacement. Klinefelter syndrome occurs if boys are born with an extra X chromosome. Males with Klinefelter syndrome should be seen by a team of health care providers. OTC. Klinefelter syndrome, also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males. Klinefelter syndrome, 47, XXY is a clinical example of sex chromosome lesions. Klinefelter syndrome. But this type of treatment is not suitable because surgery causes greater pain and also costs higher. The therapy is initiated at the time of puberty to enable the body to change normally as it should. This shall replace what the patient is lacking and require at the time of puberty. Klinefelter syndrome is a chromosomal disorder that occurs when a male is born with an additional X chromosome. Sometimes, symptoms are more evident and may include weaker muscles, greater height, poor coordination, less body hair, breast growth, and less interest in sex. Although there's no way to repair the sex chromosome changes due to Klinefelter syndrome, treatments can help minimize its effe… Klinefelter syndrome is a genetic condition that occurs when a boy is born with an extra copy of the X chromosome. People with Klinefelter syndrome can experience breast growth, breast cancer, osteoporosis, infertility and learning difficulties. This page of the eMedTV library discusses these options along with other possible treatments for Klinefelter syndrome, with links to additional information. Many boys with Klinefelter syndrome — also known as XXY syndrome — have no signs or symptoms, and some don't even know they have it until later in life.. People typically have 46 chromosomes in each cell, two of which are the sex chromosomes. J Clin EndocrinolFeaturesMetab. This is a significant treatment for the affected. Boys and men with Klinefelter syndrome are still genetically male and often will not realize they have this extra X chromosome (47, XXY), but occasionally it can cause problems that may require treatment, problems such as a small penis, small testes and infertility. We are a subspecialty program, which means that we do not offer routine primary care but instead we offer our patients a comprehensive evaluation, specific to the needs of people with Klinefelter syndrome. Therapy. Treatments Treatment with testosterone and/or a medicine to prevent excess estrogen production may be given to help normalize secondary sexual development and improve libido, strength, mood and thinking. Androgen therapy (types of testosterone) is the most common form of treatment for Klinefelter syndrome and can have a number of positive effects, including improving sex drive, promoting hair growth, increasing muscle strength and energy levels, and reducing the likelihood of osteoporosis. The following list of medications are in some way related to, or used in the treatment of this condition. Treatment with androgens reduces gynecomastia and evidence of male hypogonadism and increases strength and libido in patients with all variants of Klinefelter syndrome. Klinefelter syndrome is a sex chromosome disorder in boys and men that results from the presence of an extra X chromosome in cells. Surgery may be needed to reduce breast size. Early diagnosis along with the right treatment and support will help an individual to live a normal and productive life. Normally the cells in men's bodies have a single X chromosome along with a Y chromosome, while women's cells have two X chromosomes. Klinefelter disease is characterized by the presence of at least one extra X chromosome in boys, which leads to impaired puberty in them. The primary features are infertility and small poorly functioning testicles. https://patient.info/mens-health/klinefelters-syndrome-leaflet Testosterone therapy can help with many of the symptoms of Klinefelter syndrome. Klinefelter syndrome can often be managed through regular checkups, medications, and counseling. Klinefelter syndrome is a congenital (present at birth) condition that affects about 1 in 1,000 men. Treatment One of the hallmarks of Klinefelter syndrome is hypergonadotropic hypogonadism, a condition that results in testosterone deficiency. 2013 (98): 20 –30 Frequency (%) Infertility (adults) Small testes Azoospermia (adults) 91-99 >95 >95 Learning disabilities (children) If treatment is needed, it’s recommended that they begin as early as possible, preferably during puberty or childhood. Treatment can help males overcome many of the physical, social, and learning problems associated with the syndrome. Clinical findings are nonspecific during childhood; thus, the diagnosis commonly is … If you or your son is diagnosed with Klinefelter syndrome, your health care team may include a doctor who specializes in diagnosing and treating disorders involving the body's glands and hormones (endocrinologist), a speech therapist, a pediatrician, a physical therapist, a genetic counselor, a reproductive medicine or infertility specialist, and a counselor or psychologist. Management of Klinefelter Syndrome: The management of Klinefelter syndrome in the Allopathy medicine system is done with Psychological counseling, Fertility treatment, Breast tissue removal, and Testosterone replacement therapy. Treatment Options for Klinefelter Syndrome . Drugs used to treat Klinefelter Syndrome. However, most men can expect to live a long, full life. Intellig Select drug class All drug classes androgens and anabolic steroids (1) Rx. 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